Earn all trophies.
Finish the game on Hard difficulty.
Collect all of only one color of Leech Charms.
Obtain all weapons.
Finish the game without combining herbs.
Finish the game without using a recovery item (including Green Chemicals).
Finish the game without using a First-Aid Spray.
Finish the game with rank S.
Defeat 16 bats in the church.
Defeat Mimicry Marcus for the first time only using a knife.
Kill 50 enemies with the Death Stare at full charge.
Put on Team Wesker costume.
Defeat all bosses except Centurion using Rebecca.
Finish the game without saving.
Finish Leech Hunter with rank A.
Defeat all enemies in Leech Hunter.
Finish Leech Hunter with rank E or above.
Play Leech Hunter.
Read all files.
Defeat Queen Leech.
Complete the treatment plant.
Obtain all keys and use them all.
Defeat the Proto Tyrant.
Combine every type of herb with each other.
Try to push something heavy with Rebecca.
Complete the factory.
Fight off the Proto Tyrant.
Shoot down a Hunter or an Eliminator while they are jump attacking in the air.
Complete the laboratory.
Defeat Infected Bat.
Get picked up by the Infected Bat.
Complete the training facility.
Play the piano using Rebecca.
Create a Custom Handgun.
Attack an enemy to save your partner who is grappling with that enemy.
Use a Green Chemical.
Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.
Destroy a zombie's legs.
Change into a costume.
Defeat Centurion.
Defeat an enemy with a critical-hit headshot.
Defeat a zombie by stomping on them.
Defeat an enemy by burning them.
Complete the train.
Create a Molotov Cocktail.
Defeat Stinger.
Defeat an enemy with a knife.
Break free of a Cerberus while they are biting you or trying to push you down.