Earn all trophies.
Complete the laboratory.
Complete the factory.
Complete the treatment plant.
Finish the game with rank S.
Finish the game on Hard difficulty.
Finish the game without combining herbs.
Finish the game without saving.
Finish the game without using a First-Aid Spray.
Finish the game without using a recovery item (including Green Chemicals).
Defeat Infected Bat.
Fight off the Proto Tyrant.
Defeat the Proto Tyrant.
Defeat Queen Leech.
Defeat all bosses except Centurion using Rebecca.
Change into a costume.
Destroy a zombie's legs.
Use a Green Chemical.
Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.
Read all files.
Obtain all keys and use them all.
Defeat Mimicry Marcus for the first time only using a knife.
Combine every type of herb with each other.
Obtain all weapons.
Defeat 16 bats in the church.
Put on Team Wesker costume.
Play Leech Hunter.
Finish Leech Hunter with rank A.
Finish Leech Hunter with rank E or above.
Collect all of only one color of Leech Charms.
Defeat all enemies in Leech Hunter.
Kill 50 enemies with the Death Stare at full charge.
Defeat an enemy with a knife.
Get picked up by the Infected Bat.
Complete the training facility.
Play the piano using Rebecca.
Shoot down a Hunter or an Eliminator while they are jump attacking in the air.
Create a Custom Handgun.
Attack an enemy to save your partner who is grappling with that enemy.
Defeat a zombie by stomping on them.
Try to push something heavy with Rebecca.
Defeat Centurion.
Complete the train.
Defeat an enemy by burning them.
Create a Molotov Cocktail.
Defeat an enemy with a critical-hit headshot.
Defeat Stinger.
Break free of a Cerberus while they are biting you or trying to push you down.