Earn all trophies.
Finish the game on Hard difficulty.
Change into a costume.
Put on Team Wesker costume.
Finish the game without using a recovery item (including Green Chemicals).
Finish the game without using a First-Aid Spray.
Finish the game without combining herbs.
Kill 50 enemies with the Death Stare at full charge.
Defeat Mimicry Marcus for the first time only using a knife.
Obtain all weapons.
Defeat all bosses except Centurion using Rebecca.
Finish the game without saving.
Finish the game with rank S.
Collect all of only one color of Leech Charms.
Finish Leech Hunter with rank E or above.
Play Leech Hunter.
Finish Leech Hunter with rank A.
Defeat all enemies in Leech Hunter.
Defeat Queen Leech.
Complete the treatment plant.
Read all files.
Obtain all keys and use them all.
Attack an enemy to save your partner who is grappling with that enemy.
Defeat the Proto Tyrant.
Complete the factory.
Fight off the Proto Tyrant.
Complete the laboratory.
Defeat Infected Bat.
Defeat 16 bats in the church.
Get picked up by the Infected Bat.
Complete the training facility.
Play the piano using Rebecca.
Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.
Combine every type of herb with each other.
Create a Custom Handgun.
Shoot down a Hunter or an Eliminator while they are jump attacking in the air.
Defeat a zombie by stomping on them.
Use a Green Chemical.
Try to push something heavy with Rebecca.
Destroy a zombie's legs.
Defeat Centurion.
Defeat an enemy by burning them.
Create a Molotov Cocktail.
Complete the train.
Defeat an enemy with a critical-hit headshot.
Defeat Stinger.
Defeat an enemy with a knife.
Break free of a Cerberus while they are biting you or trying to push you down.