Earn all trophies.
Finish the game on Hard difficulty.
Obtain all weapons.
Put on Team Wesker costume.
Change into a costume.
Kill 50 enemies with the Death Stare at full charge.
Defeat Mimicry Marcus for the first time only using a knife.
Defeat all bosses except Centurion using Rebecca.
Finish the game without using a recovery item (including Green Chemicals).
Finish the game without saving.
Finish the game without combining herbs.
Collect all of only one color of Leech Charms.
Finish Leech Hunter with rank E or above.
Finish Leech Hunter with rank A.
Play Leech Hunter.
Defeat all enemies in Leech Hunter.
Defeat Queen Leech.
Finish the game without using a First-Aid Spray.
Finish the game with rank S.
Complete the treatment plant.
Read all files.
Obtain all keys and use them all.
Defeat the Proto Tyrant.
Complete the factory.
Fight off the Proto Tyrant.
Complete the laboratory.
Defeat Infected Bat.
Defeat 16 bats in the church.
Get picked up by the Infected Bat.
Create a Custom Handgun.
Complete the training facility.
Play the piano using Rebecca.
Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.
Combine every type of herb with each other.
Shoot down a Hunter or an Eliminator while they are jump attacking in the air.
Use a Green Chemical.
Try to push something heavy with Rebecca.
Attack an enemy to save your partner who is grappling with that enemy.
Defeat a zombie by stomping on them.
Destroy a zombie's legs.
Defeat Centurion.
Defeat an enemy by burning them.
Complete the train.
Create a Molotov Cocktail.
Defeat an enemy with a critical-hit headshot.
Defeat an enemy with a knife.
Defeat Stinger.
Break free of a Cerberus while they are biting you or trying to push you down.