Earn all trophies.
Finish the game on Hard difficulty.
Obtain all weapons.
Finish the game without using a recovery item (including Green Chemicals).
Finish the game without combining herbs.
Finish the game with rank S.
Finish the game without using a First-Aid Spray.
Put on Team Wesker costume.
Defeat all bosses except Centurion using Rebecca.
Finish the game without saving.
Kill 50 enemies with the Death Stare at full charge.
Collect all of only one color of Leech Charms.
Finish Leech Hunter with rank E or above.
Finish Leech Hunter with rank A.
Defeat all enemies in Leech Hunter.
Defeat 16 bats in the church.
Combine every type of herb with each other.
Defeat Mimicry Marcus for the first time only using a knife.
Play Leech Hunter.
Defeat an enemy with a knife.
Complete the treatment plant.
Defeat Queen Leech.
Read all files.
Obtain all keys and use them all.
Defeat the Proto Tyrant.
Destroy a zombie's legs.
Complete the factory.
Fight off the Proto Tyrant.
Complete the laboratory.
Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.
Defeat Infected Bat.
Get picked up by the Infected Bat.
Complete the training facility.
Create a Custom Handgun.
Play the piano using Rebecca.
Shoot down a Hunter or an Eliminator while they are jump attacking in the air.
Defeat a zombie by stomping on them.
Defeat an enemy by burning them.
Use a Green Chemical.
Try to push something heavy with Rebecca.
Defeat an enemy with a critical-hit headshot.
Defeat Centurion.
Change into a costume.
Attack an enemy to save your partner who is grappling with that enemy.
Complete the train.
Create a Molotov Cocktail.
Defeat Stinger.
Break free of a Cerberus while they are biting you or trying to push you down.