Acquire all trophies.
Clear all Bloody Palace stages with all characters.
Clear all Bloody Palace stages with Trish.
Clear all Bloody Palace stages with Dante.
Defeat Dante in the Bloody Palace without taking any damage.
Clear all Bloody Palace stages with Vergil.
Clear all Bloody Palace stages with Nero.
Defeat 10,000 enemies.
Clear all game modes.
Clear the Bloody Palace in Turbo Mode.
Clear the Bloody Palace within 2 hours.
Clear all Bloody Palace Mode stages with an S ranking.
Clear all Bloody Palace stages with Lady.
Clear all missions in Hell and Hell Mode.
Clear the game with Vergil.
Clear all missions in Heaven or Hell Mode.
Clear all missions in Legendary Dark Knight Mode.
Clear all missions in Legendary Dark Knight Mode with an S Ranking.
Defeat 10 enemies within 1 second.
Clear all missions in Dante Must Die Mode with an S ranking.
Clear all missions in Dante Must Die Mode.
Defeat Angelo Credo with an SSS ranking in Son of Sparda Mode or higher.
Defeat Dante with an SSS ranking in Son of Sparda Mode or higher.
Defeat The Savior with an SSS ranking in Son of Sparda Mode or higher.
Clear all missions in Son of Sparda Mode.
Clear all missions in Son of Sparda Mode with an S ranking.
Defeat Bael or Dagon with an SSS ranking in Son of Sparda Mode or higher.
Defeat Berial with an SSS ranking in Son of Sparda Mode or higher.
Defeat Angelo Agnus with an SSS ranking in Son of Sparda Mode or higher.
Defeat Echidna with an SSS ranking in Son of Sparda Mode or higher.
Clear all missions in Devil Hunter Mode with an S ranking.
Acquire all of Dante's skills.
Clear the game with Lady and Trish.
Clear all missions in Human Mode with an S ranking.
Clear all missions in Human Mode.
Clear all missions in Devil Hunter Mode.
Acquire all of Nero's skills.
Defeat 1,000 enemies.
Clear all secret missions.
Defeat 100 enemies.
Complete a Stylish Rank SSS (Smokin' Sick Style!!!) combo.
Complete a Stylish Rank SS (Smokin' Style!!) combo.
Complete a Stylish Rank S (Smokin'!) combo.