Earn all trophies.
Finish the game with rank S.
Finish the game on Hard difficulty.
Finish the game without combining herbs.
Finish the game without saving.
Finish the game without using a First-Aid Spray.
Finish the game without using a recovery item (including Green Chemicals).
Defeat all bosses except Centurion using Rebecca.
Defeat an enemy with a knife.
Read all files.
Obtain all keys and use them all.
Defeat Mimicry Marcus for the first time only using a knife.
Combine every type of herb with each other.
Obtain all weapons.
Defeat 16 bats in the church.
Put on Team Wesker costume.
Finish Leech Hunter with rank A.
Finish Leech Hunter with rank E or above.
Collect all of only one color of Leech Charms.
Defeat all enemies in Leech Hunter.
Kill 50 enemies with the Death Stare at full charge.
Play Leech Hunter.
Break free of a Cerberus while they are biting you or trying to push you down.
Complete the treatment plant.
Defeat Queen Leech.
Defeat the Proto Tyrant.
Try to push something heavy with Rebecca.
Complete the factory.
Fight off the Proto Tyrant.
Complete the laboratory.
Get picked up by the Infected Bat.
Destroy a zombie's legs.
Play the piano using Rebecca.
Use a Green Chemical.
Defeat Infected Bat.
Complete the training facility.
Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.
Defeat an enemy by burning them.
Create a Custom Handgun.
Shoot down a Hunter or an Eliminator while they are jump attacking in the air.
Defeat a zombie by stomping on them.
Defeat Centurion.
Create a Molotov Cocktail.
Complete the train.
Attack an enemy to save your partner who is grappling with that enemy.
Defeat an enemy with a critical-hit headshot.
Defeat Stinger.
Change into a costume.