Complete Chapter 1: "Worlds Apart"

Complete Chapter 2: "Another Day at the Office"

Complete Chapter 3: "Return to the Megavents"

Complete Chapter 4: "Rendezvous with Fate"

Complete Chapter 5: "Emergency Care"

Complete Chapter 6: "Nowhere to Hide"

Complete Chapter 7: "Life and Death"

Complete Chapter 8: "In the Hearts of Men"

Complete Chapter 9: "Escaping the Ishimura"

Complete Chapter 10: "Secrets and Salvation"

Beat the top score on the "Extraction Site" Challenge

Beat the top score on the "Central Plaza" Challenge

Beat the top score on the "Maintenance Bay" Challenge

Beat the top score on the "Mess Hall" Challenge

Beat the top score on the "Medical Bay" Challenge

Beat the top score on the "Water Tunnels" Challenge

Beat the top score on the "East Grow Chamber" Challenge

Beat the top score on the "Shuttle Bay 47" Challenge

Beat the top score on the "Atrium" Challenge

Beat the top score on the "Life Support Room" Challenge

Survive the shuttle flight with less than 10% shields intact

Play cooperatively with a second player

Shoot the box hanging from the crane on the surface of Aegis 7

Open the secret weapons store in P-Sec

Take a minor detour in the megavents

Admire the view in the crashed shuttle

Complete any level with at least 80% Perfect Reloads

Complete any level with at least 80% Weapon Accuracy

Complete any level with at least 80% Stasis Accuracy

Complete any level with a 5 star rating

Earn 10 stars on one profile

Collect all weapons, text logs and audio logs on Chapter 1: "Worlds Apart"

Collect all weapons, text logs and audio logs on Chapter 3: "Return to the Megavents"

Collect all weapons, text logs and audio logs on Chapter 5: "Emergency Care"

Collect all weapons, text logs and audio logs on Chapter 8: "In The Hearts of Men"

Collect all weapons, text logs and audio logs on Chapter 9: "Escaping the Ishimura"