Complete Act 1 on any difficulty level

Complete Act 2 on any difficulty level

Complete Act 3 on any difficulty level

Complete all chapters on Normal

Defeat Anti-Venom on any difficulty level

Defeat Black Cat on any difficulty level

Defeat Atrocity on any difficulty level

Defeat the CEO on any difficulty level

Spider-Man is down and out

Foresee the death of Spider-Man

Erase the Prototype Combat Robot from existence

Reach Floor 66

Stop the future from becoming a radioactive wasteland

Collect all three Atomic Fuses

Gain access to the Restricted Archives Computer

Gain access to the Future Restricted Area

Analyze all Data Modules

Retrieve all three DNA Samples from the knocked-out Atrocity

Bring the Incinerator to Maximum Power

Teleport back to Alchemax with the Key

Save Mary Jane

Defeat 100 enemies

Web of Challenges - Obtain All Gold Medals for a Chapter

Obtain 1/4 of the Golden Spiders

Buy all Combat Upgrades

Obtain all Alternate Suits

Obtain all Newspapers

Avoid 100 Attacks with Accelerated Decoy

Evade 100 attacks with Hyper-Sense

Execute a 50-hit combo

Execute a 100-hit combo

Execute a 200-hit combo

Collect 500 Orb Fragments

Complete Session 3 or later without dying

Complete a Freefall section by boosting the entire time

Perform 3 of each type of Grab Attack on enemies

Perform 3 of each Air Attack on enemies

Damage enemies with Roundhouse Spin and Web Hammer 10 times each