Complete Mission 1 on Normal difficulty with at least 10 amoebas alive.

Complete Mission 2 on Normal difficulty without losing a single amoeba.

Complete Mission 2 on Normal difficulty without replicating more than 16 times.

Complete Mission 3 on Normal difficulty without replicating.

Complete Mission 3 on Normal difficulty without using the Cryo Probe.

Complete Mission 4 on Normal difficulty without letting an amoeba escape.

Complete Mission 4 on Normal difficulty without replicating more than 15 times.

Complete Mission 5 on Normal difficulty without allowing more than 5 cysts to hatch.

Complete Mission 5 on Normal difficulty without allowing the Analysis Probe to take damage.

Complete Mission 6 on Normal difficulty without losing a single amoeba.

Complete Mission 6 on Normal difficulty by killing at least 60% of the enemy amoebas yourself.

Complete Mission 7 on Normal difficulty without losing any units to the Chaos Amoeba.

Complete Mission 7 on Normal difficulty without using the Poison Probe.

Complete Mission 8 on Normal difficulty without replicating.

Complete Mission 8 on Normal difficulty without using meteors to kill Alphas.

Complete Mission 9 on Normal difficulty without replicating.

Complete Mission 9 on Normal difficulty by eliminating all enemy amoebas.

Complete Mission 10 on Normal difficulty without allowing the Queen to take damage.

Complete Mission 10 on Normal difficulty by purifying at least 50% of the Ursas.

Complete Mission 11 on Normal difficulty with at least 10 amoebas alive.

Complete Mission 11 on Normal difficulty without mutating or purifying any amoebas.

Complete Mission 12 on Normal difficulty without allowing the Proteus Cyst to take damage.

Complete Mission 12 on Normal difficulty without deploying a single probe.

Complete the campaign on Veteran difficulty.