Complete the story stage "Awakening the Monolith"

Complete the story stage "Finding Allies"

Defeat the Shub-Niggurath boss fight

Defeat the Dagon boss fight

Defeat the Ithaqua boss fight

Defeat the Hastur boss fight

Complete the story stage "Tension rises"

Complete the story stage "The Betrayal"

Unlock all starting decks in campaign mode

Upgrade any building to maximum level in campagn mode (except for Propaganda Center)

Complete the story stage "The Last Hope"

Defeat the Azathoth boss fight

Collect the "Anti-Clotting Lubricant" collection

Collect the "Deedstalker" collection

Complete 3 acts in campaign mode as a Detective

Complete 3 acts in campaign mode as a Professor

Defeat the Cthulhu boss fight

Complete the campaign mode story

Complete the story stage "The Final"

Collect the "Elephant Figurine" collection

Collect the "Vampire Jaw" collection

Constuct all the buildings in campaign mode

Collect the "On the Origin of Species" collection

Collect the "Merchant Guild Medalion" collection

Collect the "Neurotoxins Grimoire" collection

Collect the "Eye of Providence Amulet" collection

Complete 3 acts in campaign mode as a Cultist

Collect the "Turban" collection

Collect the "Pith Helmet" collection

Collect the "Card Shark Deck" collection

Collect the "Ice Crown" collection*

Collect the "Pharaoh's Mask" collection

Finish investigating Head's case

Finish investigating Grim's case

Finish investigating Hand's case

Finish investigating Brain's case

Finish investigating Weirdo's case

Finish investigating Julia's case

Collect the "Bonsai Tree" collection

Collect the "Accumulator" collection

Collect the "Crimson Moonstone" collection

Collect the "Straitjacket" collection

Collect the "Mystical Sphere" collection

Collect the "Tourist Backpack" collection

Collect the "Menorah" collection

Complete all investigations in campaign mode

Collect the "Tentacle of Cthulhu" collection

Collect the "Gas Mask" collection

Upgrade all buildings to maximum level in campagn mode

Collect the "Phrenology Bust" collection

Collect the "Stamped Passport" collection

Complete 3 acts as Detective in "Custom" mode on a medium difficulty with a normal number of enemies

Complete 3 acts as Professor in "Custom" mode on a medium difficulty with a normal number of enemies

Complete 3 acts as Cultist in "Custom" mode on a medium difficulty with a normal number of enemies

Complete 3 acts with a Mixed Deck in "Custom Game" mode.

Complete 3 acts on high difficulty with an increased number of enemies in "Custom Game" mode.

Complete 3 acts with a Boss Rush modifier in "Custom Game" mode.

Complete 3 acts with the "Lost" modifier in "Custom Game" mode